Relatório do Núcleo de Vigilância Epidemiológica do Hospital Estadual de Luziânia de janeiro a dezembro de 2023 / Report from the Epidemiological Surveillance Center of the Luziânia State Hospital from January to December 2023

Relatório mensal epidemiológico das atribuições realizadas pelo Núcleo Hospitalar de Epidemiologia do Hospital Estadual de Luziânia, janeiro a dezembro 2023, que tem como objetivo implementar e gerir a estratégia de vigilância epidemiológica hospitalar, por meio de monitoramentos, assessorias e promoções de capacitações, analisa e avalia a detecção das doenças, agravos e eventos de saúde pública de notificação compulsória

Monthly epidemiological report on the tasks carried out by the Hospital Nucleus of Epidemiology of the Hospital Estadual de Luziânia, January to December 2023, which aims to implement and manage the hospital epidemiological surveillance strategy, through monitoring, consultancy and training promotions, analyzes and evaluates the detection of diseases, conditions and health events public compulsory notification

Informe sífilis SE 01 a 24/2024 - Goiás / Report syphilis SE 01 to 24/2024 - Goiás

A sífilis é uma doença crônica causada pelo agente etiológico Treponema pallidum, curável exclusiva do ser humano, tem o trtamento garantido pelo Sistema Único de Saúde (SUS) e está na lista de agravos e doenças de notificação compulsória. Este informe traz os dados da sífilis notificados em Goiás de acordo com o Sistema de Informação de Agravos de Notificação (SINAN)

Syphilis is a chronic disease caused by the etiological agent Treponema pallidum, curable exclusively in humans, treatment guaranteed by the Unified Health System (SUS) and is on the list of diseases and diseases of compulsory notification. This report provides data on syphilis reported in Goiás according to the Notifiable Diseases Information System (SINAN)

Sífilis ocular, "la gran simuladora" / Ocular syphilis, "the great pretender"

Introducción: La sífilis es una enfermedad de transmisión sexual causada por el Treponema pallidum. Reportes recientes de diferentes regiones del mundo sugieren que la sífilis ocular está reemergiendo en paralelo con el incremento de la incidencia de la infección sistémica a nivel global. Objetivo: Profundizar en el conocimiento sobre la sífilis, especialmente, en la sífilis ocular, que se encuentra en la bibliografía especializada. Métodos: Fundamentalmente se consultaron artículos de los últimos 5 años, en idioma español e inglés, disponibles en textos completos. Las bases de datos consultadas fueron: PubMed, SciELO y Google académico. Conclusiones: La sífilis ocular puede presentarse en cualquier estadío de la enfermedad e imitar diferentes afecciones inflamatorias oculares, por lo que debe tenerse presente en el diagnóstico diferencial de toda uveítis. El tratamiento oportuno de estos pacientes puede minimizar el daño visual, pero su diagnóstico es a menudo un desafío para el oftalmólogo(AU)

Introduction: Syphilis is a sexually transmitted disease caused by Treponema pallidum. Recent reports from different regions of the world suggest that ocular syphilis is re-emerging, in parallel with the increasing incidence of systemic infection globally. Objective: To deepen the knowledge on syphilis and especially ocular syphilis found in the specialized literature. Methods: The articles consulted were mainly from the last 5 years, in Spanish and English, available in full text. The databases consulted were PubMed, SciELO and Google academic. Conclusions: Ocular syphilis can present at any stage of the disease and mimic different ocular inflammatory conditions, so it should be taken into account in the differential diagnosis of any uveitis. Prompt treatment of these patients can minimize visual damage but its diagnosis is often a challenge for the ophthalmologist(AU)

Epidemiological profile of gestational syphilis and congenital syphilis in a reference center in Northeast Brazil: risk factors and trend from 2019 to 2021 / Perfil epidemiológico de sífilis gestacional e sífilis congênita em centro de referência no Nordeste do Brasil: fatores de risco e tendência de 2019 a 2021

Introduction: Syphilis is an infectious systemic disease caused by the bacterium Treponema pallidum. The Amaury de Medeiros Integrated University Health Center in Recife is a reference maternity hospital for high-risk pregnancies and the management of the most common Sexually Transmitted Infections during prenatal care, including Gestational Syphilis and Congenital Syphilis. Objective: To determine the epidemiological profile of the population exposed to these conditions, the rate of Gestational Syphilis detection, the incidence of Congenital Syphilis, and the associated unfavorable outcomes in Amaury de Medeiros Integrated University Health Center between January 2019 and December 2021. Methods: This retrospective cohort study included pregnant women and neonates diagnosed with syphilis at Amaury de Medeiros Integrated University Health Center. Data were collected from the Notification/Investigation Forms for Gestational Syphilis and Congenital Syphilis, between January 2019 and December 2021. Results: At Amaury de Medeiros Integrated University Health Center, 463 cases of Gestational Syphilis and 296 of Congenital Syphilis were reported. During the three-year study, 4444, 4360, and 4265 live births were recorded, confirming the Gestational Syphilis detection rates ­ 33.30, 36.92, and 36.10 per 1000 live births, with the incidence of Congenital Syphilis being 26.1, 21.33, and 20.39 per 1000 live births. Pregnant women in their third trimester who were brown, had incomplete primary education, and lived in an urban area were the main sociodemographic variables. In total, 217 (73.3%) patients were diagnosed with Gestational Syphilis during or after delivery, indicating a low prenatal coverage (70.6%). In terms of the progression of Congenital Syphilis, unfavorable outcomes was found in 40 (13.5%) patients, including 16 (40%) abortions, 10 (25%) stillbirths, nine (22.5%) deaths from Congenital Syphilis, and 5 (12.5%) deaths from other causes. Conclusion: Gestational Syphilis detection rates and Congenital Syphilis incidence remain alarming, with abortions and stillbirths being the most common unfavorable outcomes. To change the dramatic situation of Congenital Syphilis in Brazil, the associated factors point to a poor quality of prenatal care and an urgent need to change public policies for pregnant women and newborns, in conjunction with socioeconomic assistance

Revaluation of the COVID-19 pandemic impact on the epidemiology of syphilis in Brazil

Introduction: Due to the coronavirus 2019 disease (COVID-19) pandemic, health systems worldwide have suffered interferences, with the interruption of sexual health clinics, limitation of ambulatory consults, prevention, diagnosis, and treatment of several diseases, especially syphilis, altering their epidemiology.Objective: To investigate the impact of the pandemic on syphilis diagnosis in Brazil, the main goal of this study was to update and reevaluate data from the Brazilian Unified Health System on the number of syphilis cases reported in all five Brazilian geographic regions and verify the response of the Brazilian health care to the COVID-19 pandemic. Methods: The data were retrieved from the National Disease Notification System and the Department of Chronic Conditions Diseases and Sexually Transmitted Infections and represent syphilis diagnosis in Brazil, from March to December 2017 to 2019, 2020, and 2021. Results: The increase in the number of syphilis cases was minor compared to 2020, keeping the Southeast region as the most impacted (+146.1%) and an increase of 22,633 cases throughout Brazil (+54.3%). Conclusion:Syphilis disease control measures were ineffective in 2021 as the drop in the number of cases was irrelevant compared to the years before the pandemic. The association between the increase in syphilis cases in Brazil and the COVID-19 pandemic should be further investigated to assist in decision-making processes and in the programming of health actions in addition to finding measures to raise the control of this disease.

Introdução: Em consequência da pandemia de COVID-19, os sistemas de saúde em todo o mundo sofreram interferências, com interrupção de clínicas de saúde sexual, limitação de consultas ambulatoriais, de prevenção, diagnóstico e tratamento de diversas doenças, principalmente a sífilis, alterando sua epidemiologia. Objetivo: Para investigar o impacto da pandemia no diagnóstico da sífilis no Brasil, o objetivo principal do presente estudo foi atualizar e reavaliar os dados do Sistema Único de Saúde sobre o número de casos de sífilis notificados nas cinco regiões geográficas brasileiras e verificar a resposta da atenção básica à saúde brasileira diante da pandemia de COVID-19. Métodos: Os dados foram retirados do Sistema Nacional de Notificação de Agravos e do Departamento de Doenças Crônicas e Infecções Sexualmente Transmissíveis e representam o diagnóstico de sífilis no Brasil, de março a dezembro de 2017 a 2019, 2020 e 2021. Resultados: O aumento no número de casos de sífilis foi menor em relação a 2020, mantendo-se a Região Sudeste como a mais impactada (+146,1%) e havendo aumento de 22.633 casos em todo o Brasil (+54,3%). Conclusão: As medidas de controle da sífilis foram ineficazes em 2021, pois a queda no número de casos foi irrelevante em comparação aos anos anteriores à pandemia. A associação entre o aumento dos casos de sífilis no Brasil e a pandemia de COVID-19 deve ser mais bem investigada para auxiliar nos processos de tomada de decisão e na programação das ações de saúde, além de se encontrarem medidas para elevar o controle desta doença.

Vigilância epidemiológica hospitalar de Goiás: 1ª coletânea de boletins dos núcleos hospitalares de epidemiologia / Hospital epidemiological surveillance in Goiás: 1st collection of bulletins from hospital epidemiology centers

Coletânea de 13 boletins publicados no site da Secretaria de Estado da Saúde de Goiás, que se destacaram por descrever o perfil de morbimortalidade da unidade e apresentar temas relevantes para a população do Estado de Goiás. Trata-se de um estudo descritivo, realizado com dados do período de janeiro a março de 2023, com informações provenientes das declarações de óbitos e prontuário eletrônico do paciente

Collection of 13 bulletins published on the Goiás State Department of Health website, which stood out for describing the unit's morbidity and mortality profile and presenting relevant themes for the population of the State of Goiás. This is a descriptive study, carried out with data from January to March 2023, with information from death certificates and the patient's electronic medical record

Perfil epidemiológico de sífilis gestacional no hospital público-privado em um município do oeste do Paraná / Epide miological profile of gestational syphilis in a public-private hospital in a municipality in western Paraná

Objetivo: Determinar o perfil epidemiológico da sífilis gestacional em um hospital público-privado localizado no município de Toledo, Paraná, no período de janeiro de 2017 a dezembro de 2019. Métodos: Estudo observacional, retrospectivo, com forma de abordagem quantitativa, descritiva e indireta, a partir de uma pesquisa documental em um hospital público-privado e na 20ª Regional de Saúde do Paraná, localizados no município de Toledo, Paraná, Brasil. Resultados: Foram avaliadas 163 gestantes com sífilis gestacional. A média de idade foi 24,42 anos. Entre as gestantes, 47,24% são mulheres brancas, 39,88% têm ensino médio completo, 66,26% residentes na cidade de Toledo, 98,16% realizaram pré-natal, 65,64% foram diagnosticadas no primeiro trimestre. O tratamento adequado ocorreu em 45,40% das gestantes e em 53,99% o parceiro foi tratado em conjunto. Conclusão: A sífilis gestacional apresentou predomínio em gestantes na faixa etária de 20 a 29 anos, mulheres brancas, com ensino médio completo, residentes em Toledo, Paraná. Retratou-se boa cobertura de pré-natal, assim como apontou-se o tratamento do parceiro sexual como o maior obstáculo para a gestante ser tratada adequadamente e indicou-se que a sífilis em gestantes pode ser considerada uma causa importante da ocorrência de desfechos perinatais desfavoráveis.

Objective: To determine the epidemiological profile of gestational syphilis in a public- private hospital, located in the city of Toledo, Paraná, from January 2017 to December 2019. Methods: Observational, retrospective study, with a quantitative, descriptive and indirect approach, based on a documentary research in a public-private hospital and in the 20th Regional Health of Paraná, located in the city of Toledo, Paraná, Brazil. Results: 163 pregnant women with gestational syphilis were evaluated. The average age was 24,42 years. 47,24% are white women, 39,88% have completed high school, 66,26% live in the city of Toledo. 98,16% had prenatal care, 65,64% were diagnosed in the 1st trimester. Appropriate treatment occurred in 45,40% of the pregnant women and in 53,99% the partner was treated together. Conclusion: Gestational syphilis was predominant in pregnant women aged 20 to 29 years, white women, with complete high school, living in Toledo, Paraná. It portrayed good prenatal coverage, as well as pointing out the treatment of the sexual partner as the biggest obstacle for the pregnant woman to be treated properly and indicated that syphilis in pregnant women can be considered an important cause of the occurrence of unfavorable perinatal outcomes.

Missed opportunities in preventing mother-to-child transmission of syphilis in the indigenous population in central Brazil / Oportunidades perdidas na prevenção da transmissão vertical da sífilis na população indígena do Brasil central

Abstract Objectives: to estimate the detection rate of syphilis in pregnant women, the occurrence of congenital syphilis, and the rate of mother-to-child transmission of syphilis, in addition to analyzing missed opportunities in the prevention of mother-to-child transmission in the indigenous population. Methods: descriptive study of cases of pregnant indigenous women with syphilis resulting or not in a case of congenital syphilis. The data were obtained from the Sistema de Informação de Agravos de Notificação (Information System of Notifable Diseases), the records of the Infecções Sexualmente Transmissíveis do Distrito Sanitário Especial Indígena (Sexually Transmitted Infections in the Special Indigenous Health District), and the medical records of pregnant indigenous women in 2015. The database and the calculation of syphilis rates in pregnant women, congenital syphilis, and mother-to-child transmission were carried out. Data on prenatal, diagnosis and treatment of syphilis during pregnancy were collected from the medical records. Results: the detection rate of syphilis in pregnant women reached 35.2/1,000 live births (LB), the occurrence of congenital syphilis encompassed 15.7/1.000 LB, and the rate of mother-to-child transmission was 44.8%. Six (24%) pregnant women started prenatal care in the first trimester and seven (28%) attended seven or more consultations. The diagnosis of syphilis was late and only nine (36%) women were properly treated. Conclusions: failures in the diagnosis and the adequate treatment of pregnant women with syphilis compromised the prevention of mother-to-child transmission of the disease.

Resumo Objetivos: estimar a taxa de detecção de sífilis em gestantes, a incidência de sífilis congênita e a taxa de transmissão verticalda sífilis e analisar as oportunidades perdidas na prevenção da transmissão vertical na população indígena. Métodos: estudo descritivo de casos de gestantes indígenas com sífilis que tiveram ou não como desfecho um caso de sífilis congênita. Os dados foram obtidos do Sistema de Informação de Agravos de Notificação, dos registros da área de Infecções Sexualmente Transmissíveis do Distrito Sanitário Especial Indígena e dos prontuários de gestantes indígenas, no ano de 2015. Realizou-se o relacionamento da base de dados e cálculo de taxas de sífilis em gestantes, sífilis congênita e de transmissão vertical. Nos prontuários, coletaram-se dados do pré-natal, diagnóstico e tratamento da sífilis na gestação. Resultados: a taxa de detecção de sífilis em gestantes foi de 35,2/1.000 nascidos vivos (NV), a incidência de sífilis congênita, 15,7/1.000 NV e a taxa de transmissão vertical, 44,8%. Evidenciou-se que seis (24%) gestantes iniciaram o pré-natal no primeiro trimestre e sete (28%) realizaram sete ou mais consultas. O diagnóstico de sífilis foi tardio e apenas nove (36%) realizaram adequadamente o tratamento. Conclusões: falhas no diagnóstico e no tratamento adequado de gestantes com sífilis comprometeram a prevenção da transmissão vertical da doença.

Epidemiological data on HIV-infected patients and the importance of education regarding the infection rate. An analytical cross-sectional study

Abstract BACKGROUND: Sexually transmitted diseases (STIs) are an important public health problem in all countries. Knowledge of their relationship with the various socioeconomic levels is necessary for an understanding of their epidemiology and behavior in society. OBJECTIVE: To investigate the epidemiology of human immunodeficiency virus (HIV)-positive patients and to correlate education with history of sexually transmitted diseases, especially for syphilis. DESIGN AND SETTING: Analytical cross-sectional study carried out in the city of Juiz de Fora, Minas Gerais, Brazil. METHODS: The medical records of HIV/acquired immunodeficiency syndrome (AIDS) patients who started antiretroviral therapy (ART) between January 2010 and July 2018 were assessed. These patients were attended at the specialized assistance service for HIV/AIDS) of the Department of Sexually Transmitted Diseases (STD/AIDS) of the city of Juiz de Fora. In total, 335 patients were selected. RESULTS: In our sample, 73.13% were male; 57.36% were aged between 25 and 45 years and 24.23% were over 45 years of age. Regarding sexual orientation, 61.78% were homosexual. Regarding education, 52.88% had "unskilled education", while 47.12% had "qualified education". Analysis on the relationship between schooling and syphilis, a positive relationship between qualified schooling and syphilis was observed: odds ratio = 3.588; 95% confidence interval: 1.090-11.808. CONCLUSION: Homosexual male patients are most affected by HIV. Furthermore, this disease is not limited only to individuals with low education. Syphilis should be suspected in all individuals.

Tendencias temporales en el uso de métodos de barrera durante las relaciones sexuales en Argentina y eficacia de intervenciones para promover su implementación / Trends in the use of barrier methods during sexual intercourse in Argentina and the effectiveness of interventions to promote their implementation

Durante la última década, presenciamos en Argentina un aumento de la incidencia de infecciones de transmisión sexual(ITS) vinculado con una disminución en el uso de métodos de barrera (MB). De acuerdo a la bibliografía, existen varias categorías de obstáculos para el uso de MB: desigualdades de género, dificultades económicas y/o de accesibilidad, desconfianza respecto de los MB provistos por el Estado respecto de su calidad y/o fecha de vencimiento, o bien, creencias acerca de que la utilización de MB disminuye el placer sexual o que no es necesario su uso cuando la relación de pareja es estable y/o basada en la confianza, el amor y/o la fidelidad. A partir de esta problemática, los autores de este artículo realizamos una búsqueda bibliográfica y revisamos cual es la evidencia que respalda diferentes intervenciones para promover el uso de MB. Encontramos evidencia de moderada calidad que avala la eficacia de intervenciones a nivel comunitario basadas en la teoría sociocognitiva y en el aumento de la oferta y la disponibilidad de preservativos para mejorar el conocimiento sobre el HIV y el uso de estos métodos, sin impacto sobre la incidencia de ITS a nivel poblacional. (AU)

Over the last decade, Argentina has shown an increase in the incidence of sexually transmitted infections (STIs) linked to a decrease in the use of barrier methods (BM). According to the literature, there are several categories of obstacles for the use of BM: gender inequalities, economic and/or accessibility difficulties, mistrust regarding the quality and/or expiry date of state-provided BMs, as well as beliefs that the use of BMs reduces sexual pleasure or that their use is not necessary when the couple's relationship is stable and/or based on trust, love and/or fidelity. In light of this issue, the authors of this article conducted a literature search and reviewed the evidence supporting different interventions to promote the use of BM. They found moderate quality evidence that supports the efficacy of community-level interventions based on socio-cognitive theory and on increasing the supply and availability of condoms to improve knowledge about HIV and the use of these methods, with no impact on the incidence of STIs at the population level. (AU)

Fatores associados ao diagnóstico da sífilis adquirida em usuários de um centro de testagem e aconselhamento / Factors associated with the diagnosis of acquired syphilis in users of a testing and counseling center / Factores asociados al diagnóstico de sífilis adquirida en usuarios de un centro de pruebas y asesoramiento

Objetivo: analisar a frequência de sífilis entre os usuários do Centro de Testagem e Aconselhamento de Montes Claros, Minas Gerais, e os fatores associados à infecção. Método: trata-se de um estudo transversal, com componentes descritivos e analíticos, realizado com usuários atendidos no serviço entre 2014 e 2019. Os dados foram coletados de fonte secundária, por amostragem aleatória e sistemática. Resultados: a amostra foi composta por 957 formulários de usuários e a frequência de casos de testes rápidos reagentes para sífilis foi de 11,3%, com distribuição semelhante entre os sexos. O diagnóstico da sífilis se associou de forma significativa às variáveis: situação conjugal, idade, escolaridade, quantidade de parcerias sexuais, orientação sexual e uso de drogas no último ano. Conclusão: programas de aconselhamento e testagem rápida devem ser incentivados para prevenção e diminuição das infecções sexualmente transmissíveis em Montes Claros e em todo país

Objective: to analyze the frequency of syphilis among users of the Testing and Counseling Center in Montes Claros, Minas Gerais, and the factors associated with the infection. Method: this is a cross-sectional study, with descriptive and analytical components, carried out with users seen at the service between 2014 and 2019. Data were collected from a secondary source, by random and systematic sampling. Results: the sample consisted of 957 user forms and the frequency of cases of rapid reactive tests for syphilis was 11.3%, with similar distribution between genders. The diagnosis of syphilis was significantly associated with the variables: marital status, age, education, number of sexual partners, sexual orientation and drug use in the last year. Conclusion:counseling and rapid testing programs should be encouraged to prevent and reduce sexually transmitted infections in Montes Claros and across the country

Objetivo: analizar la frecuencia de sífilis entre los usuarios del Centro de Asesoramiento y Pruebas en Montes Claros, Minas Gerais y los factores asociados a la infección. Método: se trata de un estudio transversal, con componentes descriptivos y analíticos, realizado con usuarios atendidos en el servicio entre 2014 y 2019. Los datos se recolectaron de una fuente secundaria, mediante muestreo aleatorio y sistemático. Resultados: la muestra estuvo conformada por 957 formularios de usuario y la frecuencia de casos de pruebas reactivas rápidas para sífilis fue de 11,3%, con distribución similar entre géneros. El diagnóstico de sífilis se asoció significativamente con las variables: estado civil, edad, educación, número de parejas sexuales, orientación sexual. y consumo de drogas en el último año. Conclusión: se deben fomentar los programas de asesoramiento y pruebas rápidas para prevenir y reducir las infecciones de transmisión sexual en Montes Claros y en todo el país

Perfil das gestantes diagnosticadas com sífilis durante o pré-natal ou parto admitidas em maternidade de Belo Horizonte ­ MG / Profile of pregnant women diagnosed with syphilis in the maternity in Belo Horizonte ­ MG

Objetivo: Conhecer o perfil epidemiológico e identificar fatores de risco, eficácia do diagnóstico e tratamento durante o pré-natal de pacientes com histórico de sífilis admitidas em uma maternidade de Belo Horizonte, com o intuito de atuar de forma preventiva quanto à população local. Métodos: Estudo transversal, retrospectivo, com análise de prontuários e banco de dados de notificações de sífilis congênita e em gestantes obtidos entre janeiro/2017 e dezembro/2019, referentes a pacientes admitidas para parto, internação clínica ou atendimento de urgência. Resultados: Foram identificadas 198 gestantes com idade média de 24 anos. Avaliando os dados pré-natais, 65% foram acompanhadas no risco habitual com uma média de seis consultas. Na análise do diagnóstico, 58% não possuíam registro de teste treponêmico e 31,8% apresentaram teste reagente. Entre as pacientes, 21% relataram já ter tido sífilis previamente. O esquema de tratamento em 74,7% foi penicilina benzatina 7.200.000 UI. O tratamento concomitante do parceiro era desconhecido em 46% dos casos e confirmado em 33%. Na avaliação neonatal, 95 recém-nascidos apresentaram VDRL positivo; desses, 33% apresentaram titulação maior que a diluição de 1:8. No desfecho gestacional, houve quatro decessos fetais e dois abortamentos. Conclusão: Apesar de recursos diagnósticos e terapêuticos simples e de baixo custo, o controle da sífilis na gestação mostra-se um desafio. O rastreio da infecção durante o pré-natal nem sempre acontece em momento oportuno e a taxa de reinfecção materna é significativa, mostrando que orientações para prevenção ou tratamento não foram realizadas adequadamente.(AU)

Objective: To know the epidemiological profile, identify risk factors, effectiveness of diagnosis and treatment during prenatal care of patients admitted to the Maternity in Belo Horizonte with a history of syphilis, in order to act preventively towards the local population. Methods: Cross-sectional study, retrospective study, with analysis of medical records and a database of congenital syphilis notifications and in pregnant women obtained between January/2017 and December/2019, referring to patients admitted for delivery, clinical hospitalization or emergency care. Results: 198 pregnant women with an average age of 24 years were identified. Evaluating the prenatal data, 65% were followed up at usual risk with an average of six consultations. In the analysis of the diagnosis, 58% did not have a treponemal test record and 31.8% had a reagent test. 21% of patients reported having previously had syphilis. The treatment regimen in 74.7% was benzathine penicillin 7,200,000 IU. Concomitant treatment of the partner was unknown in 46% of cases and confirmed in 33%. In the neonatal assessment, 95 newborns showed positive VDRL test, of which 33% had a higher titre than the 1:8 dilution. In the gestational outcome, there were four fetal deceases and two abortions. Conclusion: Despite simple and low-cost diagnostic and therapeutic resources, controlling syphilis during pregnancy is a challenge. Screening for infection during prenatal care does not always happen in an opportune moment and the rate of maternal reinfection is significant, showing that guidelines for prevention or treatment have not been carried out.(AU)

Assessment of the appropriate management of syphilis patients in primary health care in different regions of Brazil from 2012 to 2018 / Avaliação do manejo adequado de pacientes com sífilis na atenção primária em diferentes regiões do Brasil entre 2012 e 2018 / Evaluación de una gestión apropiada de pacientes con sífilis en la atención primaria en diferentes regiones de Brasil entre 2012 y 2018

This study aimed to analyze the presence of adequate infrastructure and work process in primary health care for the diagnosis, management, and treatment of syphilis in Brazil in 2012, 2014, and 2018. This is a cross-sectional, nationwide study with data from the three cycles of the Program for Improvement of Access and Quality of Basic Healthcare (PMAQ-AB): 2012 (Cycle I), 2014 (Cycle II), and 2018 (Cycle III). Two outcomes were assessed: adequate infrastructure and work process. The independent variables were macroregion, municipality size, Municipal Human Development Index (HDI-M), and coverage of the Family Health Strategy (FHS). Variance-weighted least squares regression was used to estimate annual changes in percentage. In total, 13,842 primary basic health units (UBS) and 17,202 professional health care teams were assessed in Cycle I; 24,055 UBS and 29,778 teams in Cycle II, and 28,939 UBS and 37,350 teams in Cycle III. About 1.4% of UBS had adequate infrastructure in Cycle I; 17.5% had in Cycle II; and 42.7% had in Cycle III. Adequate work process also increased in the three cycles, ranging from 47.3% in Cycle I to 45.5% in Cycle II and 75.4% in Cycle III. However, inequities are observed, considering that richer regions and larger municipalities, with higher HDI-M and lower FHS coverage improved the most. The low prevalence of adequate infrastructure and work process for the care of patients with syphilis in Brazil reflects a significant weakness in the Brazilian health system.

O estudo teve como objetivo analisar a presença de infraestrutura e processo de trabalho adequados na atenção primária para o diagnóstico, manejo e tratamento da sífilis no Brasil nos anos de 2012, 2014 e 2018, com um desenho transversal, de abrangência nacional, com dados dos três ciclos do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB) em 2012 (Ciclo I), 2014 (Ciclo II) e 2018 (Ciclo III). Foram avaliados dois desfechos: infraestrutura e processo de trabalho adequados. As variáveis independentes foram macrorregião, tamanho do município, Índice de Desenvolvimento Humano Municipal (IDH-M) e cobertura da Estratégia Saúde da Família (ESF). Foi utilizada regressão de mínimos quadrados ponderada pela variância para estimar as mudanças anuais em pontos percentuais. No Ciclo I, foram avaliadas 13.842 unidades básicas de saúde (UBS) e 17.202 equipes de saúde, no Ciclo II, 24.055 UBS e 29.778 equipes e no Ciclo III, 28.939 UBS e 37.350 equipes. No Ciclo I, 1,4% das UBS apresentavam infraestrutura adequada, aumentando para 17,5% no Ciclo II e 42,7% no Ciclo III. Houve também um aumento no processo de trabalho adequado nos três ciclos, passando de 47,3% no ciclo I para 45,5% no ciclo II e 75,4% no Ciclo III. Entretanto, foram observadas inequidades, com melhoras mais expressivas nas regiões mais ricas, municípios com IDH-M mais alto, maiores e com menor cobertura da ESF. A baixa prevalência de infraestrutura e processo de trabalho adequados para o atendimento dos pacientes com sífilis no Brasil refletem uma insuficiência importante no sistema de saúde brasileiro.

El objetivo de este estudio fue analizar la presencia de infraestructura adecuada, así como de la existencia de procesos laborales dentro de la atención primaria para la diagnosis, gestión y tratamiento de sífilis en Brasil durante los años de 2012, 2014 y 2018. Se trata de un estudio transversal, nacional, con datos de los tres ciclos del Programa Nacional de Mejoría de Acceso y Calidad de la Atención Básica (PMAQ-AB) en 2012 (Ciclo I), 2014 (Ciclo II) y 2018 (Ciclo III). Se evaluaron dos resultados: infraestructura adecuada y proceso laboral. Las variables independientes fueron: macrorregión, tamaño del municipio, Índice de Desarrollo Humano Municipal (HDI-M), así como la cobertura de la Estrategia Salud de la Familia (ESF). Se utilizó la regresión de mínimos cuadrados ponderados por varianza para estimar los cambios anuales por puntos porcentuales. En el Ciclo I, se evaluaron 13.842 servicios de salud básicos (UBS) y 17.202 equipos profesionales de salud, en el Ciclo II 24.055 UBS y 29.778 equipos y en el Ciclo III 28.939 UBS y 37.350 equipos. En el Ciclo I un 1.4% de las UBS tenían una infraestructura adecuada, incrementándose hasta un 17.5% en el Ciclo II y a un 42.7% en el Ciclo III. Había también un incremento en el proceso laboral adecuado en los tres Ciclos, yendo de un 47.3% en el Ciclo I al 45.5% en el Ciclo II y un 75.4% en el Ciclo III. No obstante, se observaron inequidades, con mejoras más expresivas en regiones más ricas, municipios con un HDI-M mayor y con una cobertura ESF más baja. La prevalencia baja de una infraestructura adecuada y el proceso laboral para el cuidado de pacientes con sífilis en Brasil refleja una importante debilidad en el sistema de salud brasileño.

Seroprevalencia de infecciones hemotransmisibles en donantes de sangre / Seroprevalence of transmissible infections in blood donors

Introducción. La seguridad transfusional es el objetivo primordial de los bancos de sangre, sin embargo, conlleva un alto riesgo de eventos adversos como son las infecciones transmisibles por transfusión (ITT). El conocimiento de la prevalencia de estas infecciones fue de particular interés en esta investigación, donde se determinó su frecuencia, coinfección y relación con el tipo de donantes admitidos. Metodología. Estudio observacional retrospectivo de 2017 y 2018, en el que se incluyeron todos los registros de donantes de sangre que contenían datos demográficos y resultados de los marcadores obligatorios en el país (Ecuador), tanto de pruebas serológicas como moleculares. Se obtuvo el permiso del custodio de la información y del subcomité de bioética de investigaciones en seres humanos. Para el análisis de los datos se utilizó estadística descriptiva e inferencial. Resultados. Se determinó una prevalencia del 3,18 % de resultados reactivos para una o más ITT, el rango de edad más prevalente fue de 29 a 40 años, el 89,8 % fueron donantes compensatorios, y de ellos el 90 % fueron reactivos para una o más ITT. El marcador serológico más prevalente fue el anti-core del virus de la hepatitis B (anti-HBc), seguido por el de sífilis y los anticuerpos contra el virus de la hepatitis C (VHC). La coinfección más prevalente fue con sífilis y hepatitis B. Se encontró una diferencia estadísticamente significativa entre los resultados obtenidos en las pruebas serológicas y las moleculares (x2=26,9; p=0,000). Conclusión. Las ITT en los bancos de sangre son un riesgo latente, por lo que es necesario conocer las variaciones epidemiológicas que existen en cada población. El conocimiento de la prevalencia de las ITT en donantes de sangre permite establecer nuevas estrategias de selección del donante, que garanticen la mejor seguridad posible en las transfusiones, además debe verificarse siempre la metodología utilizada y hacer monitoreo permanente del sistema de calidad establecido

Introduction. Transfusion safety is the primary objective of blood banks, however one of the adverse reactions to blood transfusion are the transfusion transmissible infections (TTIs). Knowledge of the prevalence of these infections was of particular interest in this study where we determined their frequency, co-infection and relationship with the type of donors admitted. Methodology. Retrospective observational study during 2017 and 2018, in which all blood donor records containing demographic data and results of the country's (Ecuador) mandatory serological markers of both serological and molecular tests were included. Permission was obtained from the data custodian and the Human Research Bioethics Subcommittee. Descriptive and inferential statistics were used for data analysis. Results. A prevalence of 3,18% of reactive results to one or more TTIs was determined, the most prevalent age range was 29 to 40 years, 89.8% were compensatory donors and 90% of them were reactive to one or more TTIs. The anti- core serological marker of the hepatitis B virus (anti-HBc) was the most prevalent, followed by syphilis and hepatitis C antibodies. Syphilis and hepatitis B were identified as the most prevalent coinfection. The correlation between the results obtained in the serological and molecular tests was determined to be different and statistically significant (x2=26.9; p=0.000). Conclusion. TTIs in blood banks are a latent risk, so it is necessary to know the epidemiological variations that exist in every population. Knowledge of the prevalence of TTIs in blood donors facilitates new donor selection strategies that guarantee the best possible safety in transfusions. In addition, the methodology used must always be verified and the established quality system must be permanently monitored

Analysis on psychoactive substances use in men who have sex with men in Tianjin / 中华流行病学杂志

Objective: To understand the use of psychoactive substances and its related factors in men who have sex with men (MSM) in Tianjin. Methods: A cross-sectional survey was conducted in MSM recruited in Tianjin by snowball sampling from September 2017 to December 2020, the information about their social demographic information, use of psychoactive substances and behavioral characteristics were collected, meanwhile the blood samples were taken from them for HIV/syphilis detections. Multivariate logistic regression was used to explore related factors about psychoactive substances use. Results: A total of 9 218 MSM were included in the study, in whom 43.5% (4 013/9 218) had ever used psychoactive substances, including 92.6% (3 718/4 013)who used Rush and 17.2% (692/4 013) who used multi substances. Multivariate analysis showed that, the OR of psychoactive substances use in MSM who were in Han ethnic group was 0.68 (95%CI:0.51-0.91) compared with those who were in minor ethnic group; the OR of psychoactive substances use in MSM who were married or cohabited, divorced or widowed were 0.65 (95%CI: 0.57-0.71), 0.80 (95%CI: 0.65-0.97) respectively compared with those who were unmarried; the OR of psychoactive substances use in MSM who had the first homosexual sex at age of ≥30 years was 0.57 (95%CI: 0.44-0.74) compared with those who had the first homosexual sex at age of <30 years; the OR of psychoactive substances use in local MSM in Tianjin was 1.12 (95%CI: 1.03-1.23) compared with those who were not local residents in Tianjin; the OR of psychoactive substances use in MSM with education level of college or above was 1.29 (95%CI: 1.12-1.49) compared with those with education level of junior middle school or below; the OR of psychoactive substances use in MSM who had anal sex in the past six months was 1.93 (95%CI: 1.34-2.77) compared with those who had no anal sex; the OR of psychoactive substances use in MSM who had >2 homosexual partners in the last week was 1.62 (95%CI: 1.41-1.87) compared with those who had ≤2 homosexual partners; the OR of psychoactive substances use in MSM who had homosexual commercial sex in the past six months was 1.99 (95%CI: 1.62-2.45) compared with those who had no homosexual commercial sex; the OR of psychoactive substances use in MSM who had sexually transmitted diseases in the last year was 2.39 (95%CI: 1.82-3.12) compared with those who had no sexually transmitted diseases and the OR of psychoactive substances use in MSM who received peer education services in the last year was 1.63 (95%CI: 1.50-1.78) compared with those who received no peer education services. Conclusion: The prevalence of psychoactive substances use is high in MSM in Tianjin, and there are many influencing factors. It is necessary to conduct targeted interventions according to the influencing factors.

HIV infection status in male outpatients in sexually transmitted disease clinics in Tianjin, 2016-2020 / 中华流行病学杂志

Objective: To understand the HIV infection status in male outpatients in sexually transmitted disease (STD) clinics in Tianjin from 2016 to 2020. Methods: According to the sentinel surveillance protocol, continuous cross-sectional studies were conducted between April and June during 2016-2020 to collect the information about the awareness of AIDS related knowledge, related sex behaviors, HIV infection, syphilis prevalence and HCV infection of male STD outpatients in Tianjin with a sample seize of 400 in each sentinel clinic. Results: From 2016 to 2020, a total of 4 000 male STD outpatients were surveyed. The HIV positive rate increased from 1.13% (9/800) to 2.25% (18/800) (trend χ2=14.22, P<0.001), the positive rate of syphilis increased from 9.38% (75/800) to 13.00% (104/800) (trend χ2=7.30, P=0.007) in this population during this period. The overall HCV positive rate was 0.45% (18/4 000). Multivariate logistic regression analysis showed that compared with those who were unmarried, had registered residence in Tianjin, had no temporary sexual behavior in the past 3 months, had no anal sex and had negative syphilis test result, the risk factors of HIV infection in the male STD outpatients included cohabitation (aOR=7.53, 95%CI:2.13-26.62), being from other provinces (aOR=3.64,95%CI:1.58-8.38), having temporary sexual behavior in the past 3 months (aOR=2.24,95%CI:1.03-4.89), having homosexual anal sex (aOR=85.99,95%CI:38.76-190.74) and suffering from syphilis (aOR=6.06,95%CI:3.18-11.56). Conclusion: The detection rates of HIV infection and syphilis in male STD outpatients in Tianjin showed upward trends from 2016 to 2020. Having temporary sexual behavior and anal sex, and suffering from syphilis were the main risk factors of HIV infection in male STD outpatients.

Prevalence of syphilis, HIV and toxoplasmosis in prenatal screening in the population of the northern region of the state of Rio de Janeiro, Brazil / Prevalência de Sífilis, HIV e Toxoplasmose no pré-natal em uma população no Norte Fluminense

Introduction: There is a need for studies to know the real situation and outline measures to guarantee a reduction in the rates of pregnant women diagnosed with HIV, Syphilis and Toxoplasmosis. Objective: To determine the prevalence of Syphilis, HIV and toxoplasmosis in puerperal women assisted at the largest public maternity hospital in Campos dos Goytacazes in 2016. Methods: Cross-sectional study, using secondary data from the puerperal women assisted at the largest maternity hospital in the northern region of the State of Rio de Janeiro, in the year 2016. Results: There were 970 puerperal women, with a prevalence of HIV, Syphilis and Toxoplasmosis in pregnancy of 1.6, 2.7 and 2%, respectively. Most pregnant women were diagnosed at delivery due to low serological coverage during pregnancy. Conclusion: The high prevalence of Syphilis, HIV and Toxoplasmosis in pregnancy requires efficient prenatal care for its identification and approach.

Introdução: São necessários estudos para conhecer a real situação e delinear medidas que garantam a redução dos índices de gestantes com diagnóstico de vírus da imunodeficiência humana, sífilis e toxoplasmose. Objetivo: Determinar a prevalência de sífilis, vírus da imunodeficiência humana e toxoplasmose em puérperas atendidas na maior maternidade pública de Campos dos Goytacazes (RJ) no ano de 2016. Métodos: Estudo transversal, utilizando dados secundários das puérperas atendidas na maior maternidade do Norte Fluminense no ano de 2016. Resultados: Foram 970 puérperas, com prevalência de vírus da imunodeficiência humana, sífilis e toxoplasmose na gestação de 1,6, 2,7 e 2%, respectivamente. A maioria das gestantes foi diagnosticada no momento do parto em razão da baixa cobertura sorológica durante a gestação. Conclusão: A alta prevalência de sífilis, vírus da imunodeficiência humana e toxoplasmose na gravidez requer um pré-natal eficiente para sua identificação e abordagem.

Características sociodemográficas y clínicas de la sífilis gestacional en Cali, 2018 / Sociodemographic and clinical characteristics of gestational syphilis in Cali, 2018

Resumen | Introducción. La sífilis gestacional se considera de interés en salud pública por las repercusiones que tiene en la madre y el hijo. Pese a tener protocolos para su notificación, diagnóstico y manejo, en Colombia se siguen evidenciando limitaciones en su control. Objetivo. Describir las características sociodemográficas, clínicas y de distribución espacial de las pacientes con sífilis gestacional en Cali, Colombia, en el 2018. Materiales y métodos. Se hizo un estudio transversal con 427 casos de sífilis gestacional reportados al Sistema de Vigilancia en Salud Pública (Sivigila). Para el procesamiento estadístico, se utilizó el programa R, versión 3.5.3. Las variables cualitativas se presentan como proporciones y, las cuantitativas, mediante medidas de tendencia central y dispersión, Para la distribución espacial, se usó el programa Qgis 3.0. Resultados. La razón de sífilis gestacional fue de 17 casos por 1.000 vivos (incluidos los mortinatos). El 57,1 % de las pacientes pertenecía al régimen subsidiado de salud y el 16,6 % no estaba asegurado. El 90,4 % de los casos se diagnosticó durante el embarazo; el 47,2% recibió tres dosis de penicilina y el 57,6 % de los contactos recibió tratamiento. Conclusiones. La tasa de sífilis gestacional en Cali en el 2018 fue superior a la nacional y la enfermedad se presentó con mayor frecuencia en mujeres gestantes en condición de vulnerabilidad socioeconómica, lo que coincidió con la distribución espacial en general. Se evidenció la falta de oportunidad en la detección temprana y el manejo de la infección tanto en las pacientes como en sus contactos, lo cual dificulta el control de la enfermedad y refleja la inadecuada aplicación de la ruta integral de atención en salud materno-perinatal.

Abstract | Introduction: Gestational syphilis is considered an event of public health interest given its impact on mother and child. In Colombia, despite having specific protocols for its notification, diagnosis, and management, there are still limitations in its control. Objectives: To describe the sociodemographic and clinical characteristics, as well as the spatial distribution of gestational syphilis in Cali, Colombia, in 2018. Materials and methods: We conducted a cross-sectional study of 427 gestational syphilis cases reported to the Colombian national epidemiological surveillance system (Sivigila). For the statistical processing, we used the R program, version 3.5.3. We expressed qualitative variables as proportions and quantitative ones through central tendency and dispersion measures, and to establish the spatial distribution we used the Qgis program, version 3.0. Results: The prevalence of gestational syphilis was 17 cases per 1,000 live births (including stillbirths); 57.1% of patients belonged to the subsidized healthcare system and 16.6% had no health insurance; 90.4% of cases were diagnosed during pregnancy; 47.2% of the pregnant women received three doses of penicillin, yet only 57.6% of contacts were treated. Conclusions: The prevalence of gestational syphilis in Cali during 2018 exceeded the national rate with a higher frequency among women in socioeconomic vulnerability conditions consistent with the general spatial distribution. There was a lack of opportunity in the early detection and management of the infection both among pregnant women and their contacts, which hinders the control of the disease and reflects the inadequate application of the comprehensive maternal and perinatal health care route guidelines.